Till Death Do Us...
Shiklah began treating Wade with more disdain the more time that they spent apart due to his negligence, prompting her to find different lovers that could satisfy her when Wade didn't. Deadpool's preference for the world on the surface fueled Shiklah's disdain towards humanity, eventually feeling that monsterkind had cowered underground for too long.
The breaking point for Shiklah was the death of her subject Farcus, a centuries-old senile monster who was killed by bystanders after wandering off Monster Metropolis. For the sake of the safety of her people, Shiklah used the power of the Scepter of the Manticore to mobilize armies from her kingdom and other places to annex Manhattan to Monster Metropolis.
Deadpool's makeshift plan to stop Shiklah involves retrieving Dracula from his slumber and having him control the vampires in Shiklah's army to fight back. Even though Dracula agrees to help Deadpool defeat Shiklah, he proposes to her as soon as they reunite, and they marry, estranging her marriage with Wade in the process. However, in addition to a revolt in rejection of monarchy having been incited on the citizens of Monster Metropolis, Shiklah admitted having discovered she felt uncomfortable with ruling her subjects by force. Shiklah abdicated the throne to pursue her interests and left her people to rule themselves. Dracula joined her, due to having been in retirement before Deadpool dragged him to the conflict.