Later, Stryfe gathered several young mutants like himself, who were displeased with the way mutants were treated, and formed the terrorist organization, the Mutant Liberation Front. Stryfe's technology and Zero's teleportation made the MLF one of the most dangerous organizations in existence, but they were opposed by Cable and the New Mutants, whom he later reorganized into X-Force. At one point, Stryfe ordered the massacre of the Native Americans of the Camp Verde Reservation, the original home of X-Force member Warpath, to cover up secret, illegal genetic experimentation being conducted in its vicinity. Cable worked to stop Stryfe's plans and his terrorist group, making it the priority of his new group, X-Force, and succeeded in destroying the Antarctica base of the Mutant Liberation Front.
Attempting to sow doubt and mistrust, when Weapon X battled his way into Stryfe's base and defeated the MLF, Stryfe removed his mask and stated that maybe Cable was him, or that neither was what they seemed.